IndraLab

Statements

PBA activates KCNH2. 3 / 3
| 3
reach
"Activation appears to be somewhat specific for KCNQ channels, as Shaker and hERG are not activated by PBA."
19156197
reach
"Activation by the boronic acid moiety has some specificity for the Kv7 family members (KCNQ1, KCNQ2/3, and KCNQ4) since PBA does not activate Shaker or hERG channels."
19156197
reach
"HERG inhibition is a concern for small molecule drug design; however, PBA inhibition of hERG does not appear to occur by classic inner vestibule block XREF_BIBR."
19156197