IndraLab

Statements

USP35 inhibits immune response. 6 / 6
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"Knockdown of USP35 enhances the anti-tumor immunity of malignant melanoma to oncolytic virotherapy."
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"Importantly, depletion of USP35 significantly enhances the anti-tumor immunity and synergizes with oncolytic virotherapy to suppress xenograft tumor growth of melanoma cells."
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"Both DNA or RNA induction pathways stimulate the expression of type I interferons, and USP35 knockdown enhances anti-tumor immunity in response to the oncolytic virus therapy."
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"Lastly, USP35 suppressed anti-tumor immunity of type I interferon through the STING/TBK1/IRF3 pathway and as a result, chemoresistance was induced [113,159,160,161]."
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"The knockdown of USP35 enhances the anti-tumor immunity of oncolytic viruses in malignant melanoma."
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"Given that oncolytic virus activates the RNA signaling pathway [23], we hypothesized that the knockdown of USP35 might enhance the anti-tumor immunity triggered by OVs."
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