IndraLab

Statements

UCHL1 activates HSPA5. 3 / 3
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"We found that GRP78 was significantly increased in CFs treated with UCHL1 siRNA, consistent with an investigation in SK-N-SH cells 35."
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"This study demonstrates that UCHL1 enhances cardiac fibrosis after MI by interacting with and downregulating GRP78 by ubiquitination."
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"We found that GRP78 was upregulated in TGF-beta1 stimulated CFs and a greater increase of GRP78 was observed in TGF-beta1 stimulated CFs treated with UCHL1 siRNA."
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