IndraLab

Statements

USP7 inhibits Multiple Myeloma. 2 / 3
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"A class of dual small molecule inhibitors of USP7 and USP47 has been identified to promote p53 activity and apoptosis in MM and B-cell leukemia cells in vitro and xenograft models."
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"A recent study demonstrated that inhibition of ubiquitin specific protease-7 (USP7), which normally stabilizes MDM2, triggers apoptosis in bortezomib resistant MM cells, confirming the idea of p53 downregulation as a DR mechanism in MM [XREF_BIBR]."
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