IndraLab

Statements

USP7 inhibits Multiple Myeloma. 4 / 5
| 4
reach
"Inhibition of USP7 by P5091 (compound 1) was shown to cause apoptosis of multiple myeloma cells and prolonged survival in animal xenograft models ( Chauhan et al., 2012 )."
29056420
reach
"A class of dual small molecule inhibitors of USP7 and USP47 has been identified to promote p53 activity and apoptosis in MM and B-cell leukemia cells in vitro and xenograft models."
33643919
reach
"USP7 inhibition induces apoptosis of tumor cells and prolonged survival in an experimental multiple myeloma and neuroblastoma mouse model [57,58] ."
25047417
reach
"A recent study demonstrated that inhibition of ubiquitin specific protease-7 (USP7), which normally stabilizes MDM2, triggers apoptosis in bortezomib resistant MM cells, confirming the idea of p53 downregulation as a DR mechanism in MM [XREF_BIBR]."
24327604