IndraLab

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USP22 binds BMI1. 35 / 38
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"Meanwhile, USP22 and BMI1 co-activation may be associated with GC progression and poor prognosis [ xref ]."
28415621
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"USP22 and BMI1 were positively associated with TNM staging (Figure xref )."
28415621
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"Overexpression of USP22 and BMI1 was previously associated with GC progression and therapy failure through clinical specimen analysis, and our study is consistent with these results."
28415621
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"In this study, we hypothesized RNF220 promoted the stemness and progression of colon cancer cells via the USP22-BMI1 axis, with the aim to investigate the specific role and related mechanism of RNF220 in colon cancer."
34753387
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"USP22 and BMI1 together form a multiprotein complex acting on their target homologous gene clusters."
38304522
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"USP22-BMI1 silences the Hox gene and increases tumor resistance."
38304522
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"In this study, we found that RNF220 promoted the stemness and progression of colon cancer cells via the USP22-BMI1 axis."
34753387
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"These results indicate that USP22 interacts with BMI1 and protects BMI1 from degradation through a deubiquitination mechanism in glioma cells."
29788550
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"Furthermore, our in vivo model suggested that RNF220 promoted tumor growth by regulating the USP22-BMI1 axis."
34753387
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"USP22 interacts with and deubiquitinates BMI1 for post-translational stabilization."
29788550
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"To examine whether USP22 can interact with BMI1, we coexpressed exogenous GFP-BMI1 with either the wild-type or catalytic inactive (C185S) mutant USP22 in HEK293FT cells."
29788550
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"However, BMI1 binding to USP22 was obviously decreased by C185S mutation, which suggests an interaction between USP22 and BMI1 with the affinity, in part, related to the deubiquitination activity."
29788550
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"To examine the interaction between endogenous USP22 and BMI1 in glioma cells, we used either USP22 antibody or control IgG conjugated agarose beads to immunoprecipitate endogenous BMI1 in U251 cells."
29788550
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"These results indicate that USP22 interacts with BMI1 and protects BMI1 from degradation through a deubiquitination mechanism in glioma cells."
29788550
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"In this study, we hypothesized RNF220 promoted the stemness and progression of colon cancer cells via the USP22-BMI1 axis, with the aim to investigate specific role and related mechanism of RNF220 in colon cancer."
34753387
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"To examine whether USP22 can interact with BMI1, we coexpressed exogenous GFP‐BMI1 with either the wild‐type or catalytic inactive (C185S) mutant USP22 in HEK293FT cells."
29788550
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"However, BMI1 binding to USP22 was obviously decreased by C185S mutation (Figure xref A), which suggests an interaction between USP22 and BMI1 with the affinity, in part, related to the deubiquitination activity."
29788550
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"However, it is not clear whether the USP22-BMI1 axis is involved in the maintenance of glioma stemness under cellular hypoxia."
32070708
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"To examine the interaction between endogenous USP22 and BMI1 in glioma cells, we used either USP22 antibody or control IgG‐conjugated agarose beads to immunoprecipitate endogenous BMI1 in U251 cells."
29788550
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"Taken together, we discovered that RNF220 functioned as an oncogenic factor by promoting the stemness the progression of colon cancer via the USP22-BMI1 axis, shedding lights on RNF220 as a potential therapeutic targets for colon cancer treatment from bench to clinic."
34753387
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"In this study, we discovered that RNF220 level was elevated in colorectal cancer, promoting the migration, invasion and proliferation of colorectal cancer cells through USP22-BMI1 axis."
34753387
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"However, whether the function of the USP22-BMI1 axis on biological effects of GSCs is modulated by HIF-1α in response to cellular hypoxia is not elucidated."
32070708
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"It is noteworthy that RNF220 regulates BMI1 expression via USP22, therefore, USP22-BMI1 axis was validated in this study to function in colorectal cancer progression."
34753387
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"Hypoxia-induced USP22-BMI1 axis accelerates the malignancy and stemness of glioma stem cells by regulating the HIF-1α [ xref ]."
34753387
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"In conclusion, RNF220 promoted the stemness and progression of colon cancer cells via the USP22-BMI1 axis."
34753387
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"Based on findings from our preliminary research, in the present study, function of USP22-BMI1 axis on GSCs under hypoxia condition were explored."
32070708
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"USP22-BMI1 axis are reported to be involved in the stemness of many types of cancer cells."
34753387
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"Therefore, we speculated that the expression of USP22-BMI1 axis might be related to the direct regulation of HIFs."
32070708
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"USP22, and BMI1 form a polyprotein complex that acts on its target homoeotic (Hox) gene cluster."
27920552
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"Kaplan–Meier analysis showed that high levels of USP22 and BMI1 expression were associated with poor overall survival and relapse-free survival in all of the cases and in patients treated with transcatheter arterial chemoembolization."
27920552
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"Moreover, we found that high USP22 expression was often associated with high BMI1 expression in HCC patients."
27920552
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"For TACE-treated patients, coexpression of USP22 and BMI1 was associated with poor HCC prognosis and stronger resistance to anticancer drugs."
27920552
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"USP22-BMI1 silences the Hox gene, thereby increasing tumor resistance ( xref )."
35935969
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"In hypoxic microenvironment, HIF-1α accelerates glioma cell stemness, invasion, and metastasis by regulating the USP22-BMI1 axis ( xref )."
35935969
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"These results stated that function of USP22-BMI1 axis on GSCs stemness and malignancy behaviors under hypoxia condition were mediated by HIF-1α expression."
32070708