IndraLab

Statements

P38 phosphorylates KCNB1 on S800. 5 / 6
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rlimsp
"In an attempt to ascribe a function to the P2 motif, we previously reported that HCV attenuates outward K+ currents mediated by the Kv2.1 channel in a P2 dependent manner (14), whereby channel activity was found to be impaired by inhibition of p38MAPK phosphorylation of serine 800 (S800) in the C-terminal cytoplasmic domain of Kv2.1."
23857585
sparser
"We had previously shown that p38 phosphorylation of residue S800 on Kv2.1 was a critical step necessary for the insertion of new channels into the plasma membrane, underlying the apoptotic K + current surge ( xref , xref )."
22745487
sparser
"In cortical neurons, increased currents are triggered by dual phosphorylation of Kv2.1 by Src and p38 at channel residues Y124 and S800."
22745487
rlimsp
"In turn p38MAPK phosphorylates serine 800 of Kv2.1, which is a key phosphorylation event involved in the insertion of Kv2.1 into the plasma membrane."
23857585
sparser
"CXCR4-mediated neuronal apoptosis is dependent on p38 MAPK phosphorylation of Kv2.1 at S800."
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