IndraLab

Statements

USP22 activates cell death. 4 / 5
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"While it is clear that USP22 is overexpressed in various cancer types and may promote oncogenesis by altering gene expression, cell death and cell cycle progression, emerging evidence suggests that USP22 also harbors tumor suppressor like properties."
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"USP22 accelerates necroptotic cell death in several cancer cells via regulating RIPK3 ubiquitination [55]."
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"In addition to USP2-1 , USP2-2 also caused caspase-8 activation , cleavage of poly ADP-ribose polymerase ( PARP ) , and promotion of cell death [ 78 ] ."
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"For instance, loss of ubiquitin-specific peptidase 22 expressions significantly decreases the TNF-α-induced necroptosis cell death ( Roedig et al., 2021 ), whereas, administration of pterostilbene inh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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