IndraLab

Statements

SOX9 binds USP28. 16 / 16
| 9 7
reach
"PARPi promotes the interaction between SOX9 and USP28."
40240356
sparser
"PARPi promotes the interaction between SOX9 and USP28."
40240356
sparser
"The GST pull-down assay was implemented to validate the direct interaction between SOX9 and USP28 (Fig. xref )."
40240356
sparser
"The endogenous interaction between USP28 and SOX9 was confirmed in SKOV3 and UWB1.289 cells (Fig. xref )."
40240356
sparser
"To explore the impact of PARPi on the interaction between USP28 and SOX9, cells were treated with olaparib for 48 h."
40240356
reach
"The GST pull-down assay was implemented to validate the direct interaction between SOX9 and USP28 (Fig. 2A)."
40240356
sparser
"In conclusion, these data indicated a direct interaction between USP28 and SOX9, suggesting a potential role of USP28 in the regulation of SOX9 ubiquitination."
40240356
reach
"The endogenous interaction between USP28 and SOX9 was confirmed in SKOV3 and UWB1.289 cells (Fig. 2F, G)."
40240356
reach
"To explore the impact of PARPi on the interaction between USP28 and SOX9, cells were treated with olaparib for 48 h."
40240356
reach
"The Co-IP results showed that olaparib treatment enhances the binding between USP28 and SOX9 (Fig. 2H)."
40240356
reach
"Additionally, we observed enhanced binding between USP28 and SOX9, but weakened binding between FBXW7 and SOX9 in SKOV3/Ola cells (Fig. 2K–N)."
40240356
reach
"In conclusion, these data indicated a direct interaction between USP28 and SOX9, suggesting a potential role of USP28 in the regulation of SOX9 ubiquitination."
40240356
reach
"Consistent with our previous findings that olaparib enhances the interaction between USP28 and SOX9, we also demonstrated that olaparib treatment reduces SOX9 ubiquitination."
40240356
sparser
"Consistent with our previous findings that olaparib enhances the interaction between USP28 and SOX9, we also demonstrated that olaparib treatment reduces SOX9 ubiquitination."
40240356
reach
"In conclusion, these findings suggested that USP28/SOX9 positively regulates the expression of DDR genes (SMARCA4, UIMC1, and SLX4) by binding to their promoters in ovarian cancer cells."
40240356
sparser
"In conclusion, our study showed that USP28 directly interacts with SOX9 to decrease its ubiquitination and degradation, which subsequently enhances the DNA damage repair and contributes to PARPi resistance in ovarian cancer cells."
40240356