IndraLab

Statements

LUC7L3 activates SCN5A. 5 / 5
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"The splicing factors RBM25 and LUC7L3 are elevated in human heart failure tissue and mediate truncation of SCN5A mRNA in both Jurkat cells and human embryonic stem cell derived cardiomyocytes [XREF_BIBR]."
26981310
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"LUC7L3 and RBM25 were elevated in human HF tissue and mediated abnormal SCN5A splicing regulation in the two cell types tested."
21859973
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"Two of these splicing factors, RBM25 and LUC7L3, were elevated in human heart failure tissue and mediated truncation of SCN5A mRNA in both Jurkat cells and human embryonic stem cell derived cardiomyocytes."
21859973
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"The activated RMB25 and LUC7L3 splicing complex increases SCN5A C (VC) and D (VD) variants, decreases the full-length SCN5A transcript and protein, and decreases Na + current."
24703920
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"Finally, while experimental manipulations of RBM25 and LUC7L3 were sufficient to cause or prevent SCN5A mRNA dysregulation, it remains possible that some of the other splicing factors increased in HF contribute to abnormal SCN5A splicing."
21859973