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Statements

CYLD inhibits TBK1. 8 / 8
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"The effect of CYLD was not specific to RIG-I, as CYLD also deubiquitinated and inhibited the signaling activities of TBK1 and IKKepsilon."
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"CYLD, long known as a tumor suppressor, has also been revealed to negatively regulate the activation of TBK1/IKKi ( Zhang et al., 2008 )."
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"Thus , CYLD ( cylindromatosis deubiquitinase ) and ubiquitin-specific protease 2b ( USP2b ) have been shown to limit TBK1 activation by removing K63-linked ubiquitin chains [ 33,34 ] ."
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"Our previous studies as well as others have demonstrated that A20, TAX1BP1, ABIN1 and CYLD inhibit TBK1 and IKKi by antagonizing their Lys63 linked polyubiquitation XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"CYLD also negatively regulates the IKK related kinases, IKKepsilon and TBK1, by the same mechanisms."
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"TBK1 signaling was active in these tumors as measured by elevated pCYLD and pTBK1 levels, and, in consonance with our findings in vitro, CYT387 treatment blocked CYLD phosphorylation and paradoxically increased pTBK1 (XREF_FIG)."
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"Since we have previously shown that Optn accumulates in the nucleus during the G2/M transition [XREF_BIBR], we speculated that this Optn relocation could prevent Optn and CYLD mediated inhibition of TBK1 activity."
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"USP2b and CYLD eliminate K63-connected polyubiquitin chains from TBK1 and prevent TBK1 activity [79–81] ."
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