IndraLab

Statements

KCNH2 activates cell cycle. 4 / 4
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"Cell cycle analysis further confirmed this observation, indicating that HERG1 siRNA transfection induced cell cycle arrest in the G1 phase with a significant increase in the percentage of cells in this phase (~ 16.7% in PANC-1 and ~ 16.1% in CFPAC-1)."
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"HERG1 agonist induces cell cycle arrest in G0/G1 phase."
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"HERG1 has also been shown to enhance GC cell invasion and proliferation, induce cell cycle progression in vitro, and promote tumor genesis and growth in vivo."
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"11 It also has been shown that inhibition of hERG1 current activity can inhibit proliferation in leukemic cells by promoting cell cycle arrest."
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