IndraLab

Statements

OTUD3 activates Neoplasms. 3 / 3
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"OTUD3 accelerates lung cancer cell growth and metastasis via regulating GRP78 To evaluate whether OTUD3 promotes tumor progression through regulating GRP78 , we depleted endogenous GRP78 in OTUD3-overexpressing H1299 and A549 cells and observed that the inhibition of endogenous GRP78 expression attenuated OTUD3-induced cell growth and migration ( Fig. 7a-f ) ."
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"Importantly, we found that OTUD3 acts as an oncogene to accelerate CRC tumor growth by enhancing YY1 stability while YY1 depletion reversed OTUD3 overexpression-induced tumor progression."
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"To determine whether OTUD3 promotes tumor progression by regulating YY1, we restored the expression of YY1 in endogenous OTUD3 depletion CRC cells or knocked down endogenous YY1 in OTUD3-overexpressing CRC cells."
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