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Statements

HRH1 activates KCNK18. 6 / 6
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"Evidence that TRESK is activated by histamine [8] affords speculation that the physiological role of TRESK currents is to ‘dampen’ cellular excitability in inflammatory responses."
24383077
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"Furthermore, TRESK is activated by histamine, an important mediator in local immune responses, and its activity is inhibited by addition of pyriamine, an H1 receptor antagonist [40] ."
19852929
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"The activation of TRESK by ACh and histamine is likely to be induced via Ca 2+ –calcineurin–NFAT/TRESK pathway."
19852929
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"Our preliminary data showed that histamine-induced activation of TRESK was partially blocked by pretreatment with pyrilamine, a H1 receptor antagonist."
18190784
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"Unlike ACh and glutamate, histamine activated both TRESK and TREK-2, suggesting that histamine may regulate TRESK through different mechanisms from glutamate and ACh."
18190784
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"The authors also discuss the coupling of TRESK to the histamine H1 receptor, mention that histamine can activate TRESK channels, and speculate that the physiological role of TRESK currents is to dampe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21855646