IndraLab

Statements

PTPN11 dephosphorylates OTUB1. 4 / 4
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sparser
"This led to the SHP2-dependent dephosphorylation of Src and OTUB1 (Fig. xref , D), and ODN-induced Syk activation increased sensitivity to the anti-cancer drug through regulation of SHP2/OTUB1/Raptor axis (Fig. xref )."
37330581
reach
"This study showed that cathepsin K inhibition activates SHP2, a tyrosine phosphatase, that dephosphorylates OTUB1 and destabilizes Raptor, whereas SHP2 deletion and pharmacological inhibition increase OTUB1-Y26 phosphorylation and Raptor expression."
37330581
reach
"This led to the SHP2-dependent dephosphorylation of Src and OTUB1 (Fig. 6A, D), and ODN-induced Syk activation increased sensitivity to the anti-cancer drug through regulation of SHP2/OTUB1/Raptor axis (Fig. 6H)."
37330581
sparser
"This study showed that cathepsin K inhibition activates SHP2, a tyrosine phosphatase, that dephosphorylates OTUB1 and destabilizes Raptor, whereas SHP2 deletion and pharmacological inhibition increase OTUB1-Y26 phosphorylation and Raptor expression."
37330581