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USP37 deubiquitinates ERK. 6 / 6
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"Next, we examined whether USP37 deubiquitinates ERK1/2."
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"As shown in Fig. 4 H, overexpression of wild-type USP37, but not the USP37 CS mutant, decreased ERK1/2 ubiquitination."
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"Since USP37 could deubiquitinate and stabilize ERK1/2, we next examined whether CDK2 could affect the USP37-mediated deubiquitination of ERK1/2."
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"Mechanistically, depletion of CDK2 or treatment with CDK1/2 inhibitors decreased ERK1/2 protein levels through USP37, which deubiquitinates and stabilizes ERK1/2."
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"USP37 deubiquitinates and stabilizes ERK1/2."
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"Given that USP37 is a deubiquitinase and interacts with ERK1/2, it is possible that USP37 could deubiquitinate and stabilize ERK1/2."
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