IndraLab
Statements
USP28 activates cell growth. 8 / 8
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8
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"As shown in XREF_FIG, knockdown of USP28 significantly inhibited NSCLC cell growth in both A549 and H1299 cells."
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"These results demonstrated that USP28 was functional in NSCLC cells, and promoted NSCLC cell growth by inducing STAT3 signaling."
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"Overexpression of USP28 accelerated PC cell growth, whereas USP28 knockdown impaired PC cell growth both in vitro and in vivo."
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"XREF_BIBR Previous study has reported that USP28 was overexpressed in NSCLC and overexpression of USP28 promoted NSCLC cell growth, but its mechanism was still unknown in NSCLC cells."
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"Further, we found that USP28 promoted PC cell growth by facilitating cell cycle progression and inhibiting apoptosis."
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"Furthermore, USP28 regulates the expression of MYC protein, which is essential in USP28 induced cell growth in glioma cells."
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"Importantly, USP28 promoted MYC expression, which was required for USP28 induced cell growth in human glioma."
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"Moreover, knockdown of USP28 inhibited cell growth of NSCLC cells in vitro and delayed NSCLC tumor growth in vivo."