IndraLab

Statements

USP8 inhibits CD274. 9 / 9
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"Mechanistically, USP8 inhibition increases PD-L1 protein abundance through elevating the TRAF6-mediated K63-linked ubiquitination of PD-L1 to antagonize K48-linked ubiquitination and degradation of PD-L1."
35361799
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"One salient example is USP8, which upregulates PD-L1 in PDAC via direct deubiquitination [21] but downregulates PD-L1 in CRC through counteracting TRAF6-mediated K63-linked polyubiquitination [22]."
38715050
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"Interestingly, PD-L1 downregulation mediated by USP8 inhibition or depletion was restored after treatment with the proteasome inhibitor MG132 in pancreatic cancer cells, suggesting that USP8 regulates PD-L1 via the proteasome pathway (Fig. 4m, n; Fig. S7f, g)."
36539510
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"In a recent study, the ubiquitin-specific protease 8 (USP8) has been shown to de-ubiquitinate PD-L1 in pancreatic cancer, demonstrating that USP8 intervention might increase PD-L1 blockade."
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"Collectively, the above results verified that USP8 inhibition activates cytotoxic T-lymphocytes by regulating PD-L1 stability."
36539510
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"Targeting USP8 reduces PD-L1’s level, stimulating cytotoxic T-cells, and bolstering the anti-tumor immune response, which enhances the efficacy of PD-L1-targeted immunotherapy [206]."
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"On the other hand, USP8 instead downregulates PD-L1 in lung cancer and CRC, and USP8 blockade increases the efficacy of ICB [22]."
38715050
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"Meanwhile, USP8 intervention might increase the efficacy of PD-L1 blockade."
36539510
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"Targeting USP8 enhances the efficacy of anti-PD-L1 therapy by reducing PD-L1 protein degradation and subsequently improving the activation of cytotoxic T lymphocytes and overall antitumor immunity."
38474186