IndraLab

Statements

OTUD3 decreases the amount of HSPA5. 3 / 3
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"The results showed that overexpression of OTUD3 significantly reduced the level of GRP78 ubiquitination, and the catalytically inactive mutant OTUD3 did not reduce the level of GRP78 ubiquitination."
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"A GRP78 ubiquitylation assay showed that overexpression of OTUD3 WT significantly reduced the level of GRP78 ubiquitination, and the catalytically inactive mutant C76A did not reduce the level of GRP78 ubiquitination (Fig. 3D)."
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"These data suggested that OTUD3 knockdown-induced ER stress did not affect the protein expression of Bip in the SN of mice, which might be related to the fact that the function of OTUD3 is tissue-dependent."
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