IndraLab

Statements

Reperfusion Injury activates CYLD. 4 / 4
| 4
reach
"We demonstrated that macrophage TXNIP deficiency controlled STING-mediated TBK1 function and alleviated IR-induced hepatocellular injury by regulating the cylindromatosis (CYLD)–NADPH oxidase 4 (NOX4) axis."
36035360
reach
"We found that IR stress promoted CYLD, a multifunctional deubiquitinating enzyme (DUB) that modulates the inflammatory cascade in immune cells via inhibiting the ubiquitination of key signalling molecules.20 Indeed, the CYLD protein, primarily located in the cytoplasm, is ubiquitously expressed and highly conserved in Kupffer cells of human and murine liver tissue."
36035360
reach
"Indeed, IR stress activated CYLD, NOX4, and NRF2 in ischaemic livers (Fig. 3A) and liver macrophages (Fig. S3)."
36035360
reach
"We therefore determined mRNA and protein expression of CYLD in BMDMs treated with CM from I/R injured hepatocytes."
27680285