IndraLab

Statements

ATM phosphorylates USP13. 23 / 23
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sparser
"Recent research indicates that ATM phosphorylation of USP13, following DNA damage, enables USP13 to deubiquitinate RAP80."
38702734
sparser
"In response to DNA damage, USP13 is phosphorylated by ATM, which in turn facilitates USP13 recruitment to DSBs, RAP80 deubiquitination, and triggers DDR signalling."
28569838
reach
"This result suggests that USP13 may be phosphorylated by ATM following DNA damage."
28569838
sparser
"Taken together, these results demonstrate that USP13 phosphorylation by ATM is important for USP13 recruitment to DSB sites following DNA damage and proper DDR."
28569838
sparser
"Together, these results suggest that USP13 phosphorylation by ATM is important for its recruitment to DSBs, DDR and chemo sensitivity."
28569838
sparser
"Mechanistically, USP13 is phosphorylated by ATM following DNA damage which, in turn, facilitates its DSB localization."
28569838
sparser
"This result suggests that USP13 may be phosphorylated by ATM following DNA damage."
28569838
rlimsp
"Mechanistically, USP13 is phosphorylated by ATM following DNA damage which, in turn, facilitates its DSB localization."
28569838
reach
"USP13 is phosphorylated by ATM following DNA damage."
28569838
reach
"Mechanistically, USP13 is phosphorylated by ATM following DNA damage which, in turn, facilitates its DSB localization."
28569838
sparser
"A recent study suggested that DNA damage could induce the phosphorylation of USP13 by the ATM and then activated USP13 deubiquitinated RAP80 (K75, K90, and K112)."
36188217
reach
"In response to DNA damage, USP13 is phosphorylated by ATM, which in turn facilitates USP13 recruitment to DSBs, RAP80 deubiquitination, and triggers DDR signalling."
28569838
reach
"Together, these results suggest that USP13 phosphorylation by ATM is important for its recruitment to DSBs, DDR and chemo sensitivity."
28569838
reach
"Recent research indicates that ATM phosphorylation of USP13, following DNA damage, enables USP13 to deubiquitinate RAP80."
38702734
reach
"Taken together, these results demonstrate that USP13 phosphorylation by ATM is important for USP13 recruitment to DSB sites following DNA damage and proper DDR."
28569838
reach
"Following DNA damage, phosphorylated USP13 by ATM is recruited to DNA damage sites to cleave the ubiquitin chains from more than three sites of RAP80 (K75, K90, and K112), releasing their restriction on the K63-linked ubiquitin chain, improving the focus formation of the RAP80-BRCA1 complex, and eventually facilitating DDR."
35445009
rlimsp
"This result suggests that USP13 may be phosphorylated by ATM following DNA damage."
28569838
rlimsp
"In response to DNA damage, USP13 is phosphorylated by ATM, which in turn facilitates USP13 recruitment to DSBs, RAP80 deubiquitination, and triggers DDR signalling."
28569838
rlimsp
"Together, these results suggest that USP13 phosphorylation by ATM is important for its recruitment to DSBs, DDR and chemo sensitivity."
28569838
rlimsp
"Furthermore, reconstitution of USP13 WT but not the T196A fully reversed the increase in RAP80 ubiquitination induced by USP13 deficiency (Supplementary Fig. 8d), suggesting USP13 phosphorylation by ATM is important for RAP80 deubiquitination."
28569838
rlimsp
"USP13 is phosphorylated by ATM following DNA damage."
28569838
sparser
"USP13 is phosphorylated by ATM following DNA damage."
28569838
rlimsp
"Taken together, these results demonstrate that USP13 phosphorylation by ATM is important for USP13 recruitment to DSB sites following DNA damage and proper DDR."
28569838