IndraLab

Statements

USP9X activates cell population proliferation. 27 / 32
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"So, knockdown of USP9X not only inhibited the proliferation of glioma cells in vitro, but also suppressed the tumorigenicity of primary glioma cells in vivo."
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"FAF enhanced the proliferation of human gingival fibroblasts, human skin fibroblasts, and human umbilical vein endothelial cells in subconfluent and confluent cells, suggesting that FAF might be functioning as a competence factor."
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"These data demonstrate that loss of USP9X decreases the proliferation of ReNcell VM cells but does not alter their morphology, cell death or differentiation."
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"In addition, USP9X activates glycolysis and promotes cell proliferation through pVHL."
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"Okra 250, 500, and Fam 20 group showed decreased apoptosis, inflammatory changes, erosions, ulceration, and increased cell proliferation than the ethanol group."
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"USP9X promotes tumor cell proliferation through the pVHL-HIF pathway."
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"In vitro studies revealed that knockdown of USP9X significantly inhibited the proliferation of HCC cells."
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"We estimated the capacity of FAM (2.5 X 10 (5] to synthesize DNA (3H-thymidine uptake) and RNA (3H-uridine uptake), and the activities of silica stimulated FAM to cause proliferation of mouse thymocytes (IL-1 activity) and rat lung fibroblasts (FP activity), and to produce PGE2."
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"It is possible that Usp9x promotes the proliferation of intermediate progenitor cells at the expense of NSC self-renewal in the postnatal hippocampus."
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"Activation of human peripheral blood T lymphocytes results in the production of fibroblast activating factor (FAF), a mediator which stimulates fibroblast proliferation."
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"This argues that USP9X exerts its effect and promotes proliferation at least to a certain extent through pVHL."
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"Next, we tested whether YAP1 is able to rescue the proliferation defect caused by USP9X depletion."
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"Here we show that in vivo knockdown of the deubiquitinating enzyme USP9X attenuates T-cell proliferation."
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"FAM could promote the proliferation of lymphocytes induced by ConA, raise the T cell count and regulate the T cell subsets disorder, elevate the LAK activity induced by IL-2."
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"USP9X destabilizes pVHL and promotes cell proliferation."
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"It is worth noting that the proliferation defect caused by Usp9X deficiency was observed in CD8 + T cells as well as CD4 + T cells (XREF_FIG)."
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"In breast cancer, USP9X deubiquitinates and stabilizes YAP to promote breast cancer cell proliferation and chemoresistance to therapeutic drugs XREF_BIBR."
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"USP9X possibly promotes head and neck cancer cell proliferation through the mTOR pathway."
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"In contrast, in immortalized but non tumorigenic HaCaT keratinocytes, USP9X depletion led to increase in cell proliferation, maintaining direct regulation of Notch activity."
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"By these results, we concluded that USP9X contributes to proliferation of PC3 cells through maintenance of IRS-2-Erk1/2 axis."
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"We proved that USP9X overexpression promoted proliferation and cell cycle and suppressed cell apoptosis in MCL cells."
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"When FRT tagged USP9X was introduced into USP9X -/- cells, the cell proliferation rate nearly recovered to that of WT cells, whereas overexpression of USP9X in WT cells slightly promoted cell proliferation as well."
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"USP9X and TKK promote proliferation, invasion and migration in LUAD cells77.Interestingly, USP9X exerts different functions in different cancers."
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"Moreover, knockdown of USP9x inhibited the proliferation and colony formation of osteosarcoma cells, which could be rescued by overexpression of SOX2."
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"In this manner, we found that loss of function in the deubiquitinase USP9X prevented proliferation arrest by tamoxifen, but not by the ER downregulator fulvestrant."
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"Although Usp9x has been identified as a potential regulator of stem cell function 37, decreasing Usp9x levels does not overtly diminish the proliferation of other progenitor and stem cells including, embryonic stem cells 38, T-cell progenitors 39 or pancreatic progenitors 36."
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"USP9X enhances proliferation of HCC cells and is correlated with undesirable prognosis."
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