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USP9X activates cell population proliferation. 62 / 67
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"Although Usp9x has been identified as a potential regulator of stem cell function 37, decreasing Usp9x levels does not overtly diminish the proliferation of other progenitor and stem cells including, embryonic stem cells 38, T-cell progenitors 39 or pancreatic progenitors 36."
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"USP9X promoted proliferation and cell cycle in MCL cells."
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"It is possible that Usp9x promotes the proliferation of intermediate progenitor cells at the expense of NSC self-renewal in the postnatal hippocampus."
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"Depletion of USP9X suppressed GBM cell migration, proliferation, and M2 macrophage polarization."
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"In breast cancer, USP9X deubiquitinates and stabilizes YAP to promote breast cancer cell proliferation and chemoresistance to therapeutic drugs [13]."
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"Piao et al.,[136] reported USP22 to be activated in OSCC and increased expression of USP22 exhibited a marked propensity toward highly malignant clinical behavior, lymph node metastasis, and poor survival after surgery suggesting its role as a prognostic indicator predicting the treatment outcome of OSCC.Nanayakkara et al.[137] reported that the deubiquitylating enzyme, USP9X, possibly promotes head and neck cancer cell proliferation through the mTOR pathway."
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"Taking into account the numerous functions of deubiquitinating modification observed in human tumors, DUB enzymes are important in the development of HNSCC; for example, USP9X [30] and USP22 [31] promote HNSC cell proliferation, and CYLD1 [32] and BPLF1 [33] accelerate HNSCC development by inhibiting the immune cell escape mechanism or by promoting the spread of viral infection."
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"In this manner, we found that loss of function in the deubiquitinase USP9X prevented proliferation arrest by tamoxifen, but not by the ER downregulator fulvestrant."
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"USP9X and TKK promote proliferation, invasion and migration in LUAD cells77.Interestingly, USP9X exerts different functions in different cancers."
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"The results of plate clone formation assay, CCK8 assay, cell scratch migration test, transwell assay, and flow cytometry indicated that USP9X could significantly promote the proliferation and invasion of FaDu cells, in addition to inhibiting apoptosis."
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"In breast cancer, USP9X deubiquitinates and stabilizes YAP to promote breast cancer cell proliferation and chemoresistance to therapeutic drugs XREF_BIBR."
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"These data demonstrate that loss of USP9X decreases the proliferation of ReNcell VM cells but does not alter their morphology, cell death or differentiation."
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"These differences in sensitivity appear to be directly related to the knockout efficiency of various techniques and further support the conclusion that USP9X is important for regulating RIT1-driven drug resistance.As expected, USP9X knockout impaired the proliferation of RIT1-mutant cells in erlotinib (Figure 2A)."
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"We proved that USP9X overexpression promoted proliferation and cell cycle and suppressed cell apoptosis in MCL cells."
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"This argues that USP9X exerts its effect and promotes proliferation at least to a certain extent through pVHL."
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"When FRT tagged USP9X was introduced into USP9X -/- cells, the cell proliferation rate nearly recovered to that of WT cells, whereas overexpression of USP9X in WT cells slightly promoted cell proliferation as well."
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"CCK-8 assay revealed that cell proliferation was promoted by USP9X overexpression, whereas it was inhibited by USP9X knockdown in Z-138 and Jeko-1 (Figure 2B)."
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"These results indicated that USP9X promoted proliferation and cell cycle in MCL cells."
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"Using human myeloid leukemia cells and a murine AML model, we find that genetic knockdown or pharmaceutical inhibition of USP9X inhibits leukemia cell proliferation, induces apoptosis, and delays AML development."
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"So, knockdown of USP9X not only inhibited the proliferation of glioma cells in vitro, but also suppressed the tumorigenicity of primary glioma cells in vivo."
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"USP9X and TTK modulate A549 cell proliferation and tumorigenesis."
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"Finally, to test whether USP9X promoted A549 cell proliferation through TTK, we transiently overexpressed TTK in the shUSP9X cells."
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"As both USP9X and RNF115 have been reported to promote breast cancer cell proliferation, migration, and invasion,13, 20, 21, 23 we next determined whether the biological function of USP9X in breast cancer cells depends on RNF115."
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"Our results demonstrated that transient overexpression of TTK could rescue cell proliferation suppression induced by USP9X knockdown (Figure S4C-D)."
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"Here we show that in vivo knockdown of the deubiquitinating enzyme USP9X attenuates T-cell proliferation."
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"Okra 250, 500, and Fam 20 group showed decreased apoptosis, inflammatory changes, erosions, ulceration, and increased cell proliferation than the ethanol group."
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"USP9X deficiency causes reduced proliferation, cell cycle arrest, and increased apoptosis in HGC-27 and MKN-45 cells, which can be rescued by MTH1 overexpression."
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"BrdU revealed that USP9X knockdown decreased cell proliferation."
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"FAM could promote the proliferation of lymphocytes induced by ConA, raise the T cell count and regulate the T cell subsets disorder, elevate the LAK activity induced by IL-2."
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"By these results, we concluded that USP9X contributes to proliferation of PC3 cells through maintenance of IRS-2-Erk1/2 axis."
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"Suppression of USP9X or TTK expression caused significant proliferation, migration and growth inhibition of A549 cells (Figure 3A-E and Figure 4A)."
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"By contrast, USP9X depletion causes significant proliferation inhibition in HCC cells."
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"These findings indicate that USP9X inhibition significantly inhibited tumor cell proliferation after treatment with gemcitabine, thus enhancing gemcitabine sensitivity by suppressing autophagy in vivo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pal et al. reported that overexpression of USP9X promoted the proliferation and invasion of pancreatic cancer cells [ 25 ]."
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"Knockdown of USP9x significantly suppressed the proliferation of osteosarcoma cells ( Fig. 7 B and C)."
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"USP9X destabilizes pVHL and promotes cell proliferation."
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"These results suggested that knockdown of USP9x inhibits proliferation of osteosarcoma cells with reduction of SOX2 in vivo ."
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"Whole genome shRNA screening in MCF7 cells showed a compendium of genes affecting sensitivity to tamoxifen [23] and a large scale loss-of-function genetic screen in ZR-75–1 breast cancer cells showed [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP9X overexpression in MCF-7 and MDA-MB-231 breast cancer increased cell proliferation and survival, significantly reduced the number of cells in the G1-phase cells and increased the number of cells in the S-phase cells, which were reversed by CRISPR/caspase-9 USP9X gene knockout."
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"As expected, knockdown of USP9x or using USP9x inhibitors inhibits the proliferation of osteosarcoma cell lines in vitro and in vivo ."
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"USP9X was identified to promote proliferation and cell cycle and inhibited cell apoptosis in MCL cells."
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"USP9X enhances proliferation of HCC cells and is correlated with undesirable prognosis."
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"USP9X overexpression increased MCF-7 and MDA-MB-231 cell proliferation."
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"The CCK-8 assay showed that USP9X overexpression increased MCF-7 cell and MDA-MB-231 cell proliferation significantly, with the highest increased peak at 72 h compared with the empty vector cells or wild-type cells (P<0.05), after the cells had been grown for 48 h."
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"USP9X knockout inhibited MCF-7 and MDA-MB-231 cell proliferation compared with that in the negative CRISPR/Cas9 vector-transfected cells (both, P<0.05) after the cells had been grown for 48 h (Figure 2A, 2B)."
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"Next, we tested whether YAP1 is able to rescue the proliferation defect caused by USP9X depletion."
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"In contrast, in immortalized but non tumorigenic HaCaT keratinocytes, USP9X depletion led to increase in cell proliferation, maintaining direct regulation of Notch activity."
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"The results indicate that USP9X overexpression can increase breast cancer cell proliferation, whereas USP9X gene knockout can decrease breast cancer cell proliferation."
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"27 Accordingly, our study demonstrated that USP9X increased proliferation and cell cycle in MCL cells."
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"USP9X knockdown decreased cell proliferation and cycle."
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"USP9X possibly promotes head and neck cancer cell proliferation through the mTOR pathway."
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"In addition, USP9X activates glycolysis and promotes cell proliferation through pVHL."
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"USP9X overexpression increased breast cancer cell proliferation, growth, and survival by increasing the S-phase fraction."
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"Likewise, the assessment of the typically aberrant fatty acid metabolism (FAM), which supports cancer cell proliferation, may be useful to construct prognostic risk models for HCC (86)."
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"USP9X promotes tumor cell proliferation through the pVHL-HIF pathway."
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"Thus, mild suppression of JAK/STAT pathway by low dose ruxolitinib or pharmacological inhibition of USP9X enhanced proliferation of B-ALL cells in vitro, while cytotoxicity was evident with high dose [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In vitro studies revealed that knockdown of USP9X significantly inhibited the proliferation of HCC cells."
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"We estimated the capacity of FAM (2.5 X 10 (5] to synthesize DNA (3H-thymidine uptake) and RNA (3H-uridine uptake), and the activities of silica stimulated FAM to cause proliferation of mouse thymocytes (IL-1 activity) and rat lung fibroblasts (FP activity), and to produce PGE2."
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"USP9X deficiency in HGC-27 and MKN-45 cells causes decreased proliferation, cell cycle arrest, extra apoptosis, and defective migration and invasion, which could be rescued by excessive MTH1."
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"Importantly, reintroduction of RNF115 in USP9X-depleted cells partially rescued the reduced proliferation, migration, and invasion of breast cancer cells by USP9X knockdown."
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"Furthermore, two deubiquitinating enzymes, USP9X and USP28, have significant expression in HCC and could similarly promote HCC cell proliferation by regulating the activity of this pathway (128, 129)."
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"It is worth noting that the proliferation defect caused by Usp9X deficiency was observed in CD8 + T cells as well as CD4 + T cells (XREF_FIG)."
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