IndraLab

Statements

USP10 activates autophagy. 14 / 14
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"USP10 could promote autophagy-related pathways and molecules and increase the synthesis of autophagosomes in NASH, improving steatosis, inflammation, and fibrosis."
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"Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis."
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"Spautin-1 inhibits autophagy by reducing the activity of USP10 and USP13, which promotes a major aspect of autophagy: degradation by Vps34 complexes."
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"USP10 promotes autophagy and attenuates lung fibrosis in BLM-induced lungs."
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"USP10 overexpression further increased the LC3II/LC3I ratio and suppressed p62 expression, suggesting that USP10 activated autophagy."
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"Mechanistically, USP10 mediated autophagy during IPF pathogenesis through the Sirt6-mediated AKT/mTOR signaling pathway."
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"Furthermore, the specific inhibitor to C-jun N-terminal protein kinase-1 (JNK1), DB07268, abolished USP10-induced autophagy."
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"JNK1/TSC2 signaling pathways were required for USP10-induced autophagy."
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"USP10 overexpression enhanced autophagy in BLM-treated mouse lungs."
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"USP10 has also been shown to enhance autophagy by deubiquitinating beclin-1 , a component of class-III PI3K complexes that catalyze the formation of phosphatidylinositol 3-phosphate at both autophagy initiation and autophagosome maturation steps ( 21 ) ."
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"USP10 promotes autophagy and attenuates fibrosis in MLF."
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"In vitro experiments showed that USP10 induced autophagy, cell proliferation, and invasion by enhancing ULK1 expression in OS cell lines."
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"Conversely, USP10 overexpression promoted autophagy activity (Fig. 7A)."
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"Consistently, the suppression of the AKT/mTOR pathway by USP10 was detected in our study, and these data further confirmed that USP10 promoted autophagy in IPF.To identify the potential target of IPF, publicly available microarray databases were performed to explore gene expression in IPF."
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