IndraLab

Statements

USP10 activates autophagy. 5 / 5
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"JNK1/TSC2 signaling pathways were required for USP10-induced autophagy."
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"USP10 could promote autophagy-related pathways and molecules and increase the synthesis of autophagosomes in NASH, improving steatosis, inflammation, and fibrosis."
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"Spautin-1 inhibits autophagy by reducing the activity of USP10 and USP13, which promotes a major aspect of autophagy: degradation by Vps34 complexes."
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"USP10 has also been shown to enhance autophagy by deubiquitinating beclin-1 , a component of class-III PI3K complexes that catalyze the formation of phosphatidylinositol 3-phosphate at both autophagy initiation and autophagosome maturation steps ( 21 ) ."
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"Furthermore, the specific inhibitor to C-jun N-terminal protein kinase-1 (JNK1), DB07268, abolished USP10-induced autophagy."
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