IndraLab

Statements

Silibinin inhibits STAT1. 2 / 3
| 2
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"In an experiment, silymarin reduced signal transducer and activator of transcription-1 (STAT-1), p38 mitogen-activated protein kinases (MAPKs) and caspase-3 and 9 during cerebral IR (91)."
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"In addition, IS induces STAT1 expression, which is an important mediator of pro inflammatory cytokines, such as IL-1beta and TNF-alpha, and STAT1 inhibition by silymarin ameliorated inflammation mediated brain tissue injury."
| PMC