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USP25 activates TRAF3. 7 / 7
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"In addition, Lin et al. found that USP25, a deubiquitinating enzyme similar to USP5, promotes IRF3 and NF-κB activation and subsequent type I interferon and proinflammatory cytokine production after viral infection by stabilizing TRAF3 and TRAF6 [82]."
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"USP25 has been shown to enhance the stability of TRAF3 and TRAF6 [XREF_BIBR]."
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"Because USP25 interacted with TRAF3 after stimulation with LPS and because the enzyme activity of USP25 was required for its regulation of TLR4 signaling (XREF_FIG and XREF_FIG), we hypothesized that USP25 might target TRAF3 for deubiquitination in response to LPS."
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"Thus, by inhibiting the degradation of TRAF3 during TLR4 activation, USP25 enables a balanced innate immune response."
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"Lin et al36 and Zhong et al37 reported that USP25 mediates innate immune responses such as antiviral and antibacterial infection by regulating TRAF3 and/or TRAF6 degradation through K48-linked polyubiquitination."
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"Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6."
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"Thus, USP25 is a critical regulator of ET and prevents the degradation of TRAF3 [18,78] ( Fig. 5 )."
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