IndraLab

Statements

USP25 activates TRAF3. 4 / 4
| 4
reach
"Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6."
26305951
reach
"USP25 has been shown to enhance the stability of TRAF3 and TRAF6 [XREF_BIBR]."
29734366
reach
"Because USP25 interacted with TRAF3 after stimulation with LPS and because the enzyme activity of USP25 was required for its regulation of TLR4 signaling (XREF_FIG and XREF_FIG), we hypothesized that USP25 might target TRAF3 for deubiquitination in response to LPS."
23674823
reach
"Thus, by inhibiting the degradation of TRAF3 during TLR4 activation, USP25 enables a balanced innate immune response."
23674823