IndraLab

Statements

CYLD inhibits Carcinogenesis. 8 / 8
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"Deficiency of either Itch or CYLD, essential ubiquitin modulators for TAK1 inactivation, enhances tumor-associated macrophage-induced inflammation, tumorigenesis, and metastasis in a Lewis lung carcin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22795313
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"In line with this, the loss of CYLD promotes Akt hyperubiquitination and activation, as well as cell proliferation, survival and prostate tumorigenesis [120]."
36769122
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"Interestingly, CYLD deficiency has been shown to promote PCa cell proliferation, cell survival, and tumorigenesis, and CYLD abundance is reduced in advanced-stage PCa samples, suggesting that CYLD may play a tumour-suppressive role in PCa [13]."
36009554
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"CYLD is an important suppressor in tumorigenesis and development."
38287022
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"In contrast, expression of the wild type CYLD inhibited SCC tumorigenesis and AP1 function."
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"Therefore, CYLD can inhibit tumorigenesis by multiple mechanisms which is consistent with the implication of its deregulation in multiple types of malignancies.CYLD expression can be modulated by tran[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27865894
eidos
"Functionally , CYLD inhibits cell proliferation and tumorigenesis through p18 in vivo ."
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"Inhibition of CYLD increases resistance to apoptosis, suggesting a mechanism through which loss of CYLD might contribute to oncogenesis."
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