IndraLab

Statements

HULC inhibits USP22. 3 / 3
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reach
"MiR-6825-5p, miR-6845-5p, and miR-6886-3p were down-regulated by HULC, resulting in the elevation of Sirt1, USP22, and protective autophagy, thus attenuating the sensitivity of HCC cells to chemotherapeutic agents [82]."
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"In HepG2 and Hep3B cells, HULC downregulates miR-6825-5p, miR-6845-5p, and miR-6886-3p, resulting in the upregulation of their target ubiquitin-specific peptidase 22 (USP22) and the inhibition of ubiquitin-mediated degradation of SIRT1 [81]."
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reach
"By enhancing ubiquitin-specific peptidase 22, HULC suppresses ubiquitin-mediated degradation of cyclooxygenase-2 and silent information regulator 1 in HCC[118]."
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