IndraLab

Statements

USP3 deubiquitinates TRAF6. 4 / 4
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"We found that USP3 interacted with TRAF6 and attenuated the polyubiquitination of TRAF6 induced by IL-1β, thereby negatively regulating NF-κB activation."
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
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"Moreover, USP3 can reverse the ubiquitination of TRAF6 (tumor necrosis factor-receptor-associated factor 6), which intermediates the signals from inflammatory cytokines to NF-κB activation, thus blocking IL-1β-induced chondrocyte apoptosis [27]."
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"Meanwhile, USP3 had little effect on the expression of TRAF6, but notably reduced TRAF6 ubiquitination."
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