IndraLab

Statements

CACNA1A inhibits Calcium_channels. 7 / 7
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"As predicted by the genetic variant, patch clamp analysis revealed reduced L-type calcium channel voltage-dependent inactivation in Timothy syndrome iPSC-CMs."
24632794
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"This gain-of-function mutation results in an impaired open-state voltage-dependent inactivation of the L-type calcium channel, ultimately leading to a markedly prolonged myocardial action potential [ xref , xref ]."
21915623
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"This mutation greatly reduces voltage-dependent inactivation of the calcium channel with little effect on calcium-dependent inactivation ( xref ), and thus may potentially cause a pathogenic calcium overload in cardiac and neuronal cells."
22705413
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"In contrast, the cyclin-dependent kinase inhibitor roscovitine, which enhances voltage-dependent inactivation of the L-type calcium channel, was able to decrease the number of tyrosine hydroxylase neurons xref ."
26826498
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"These gain-of-function mutations result in an impaired open-state and voltage-dependent inactivation of the L-type calcium channel, ultimately leading to a markedly prolonged myocardial action potential (delayed ventricular repolarization) ( xref - xref )."
26301350
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"In all experiments γ-5 had no significant effect on the modulation of voltage-dependent activation and inactivation of the α 1A calcium channel."
10734232
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"We took advantage of a mouse KO strain defective for Cacna1a (Jun et al., 1999) which encodes the P/Q-type Ca 2.1 calcium channel to decrease presynaptic calcium channel function, in order to genetically mimic this effect on OIRD sensitivity."
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