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UCHL5 inhibits HMBS. 3 / 3
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"Most importantly, it was shown that loss of uchl5, the human orthologue of ubh-4, also increases UPS activity and the degradation of proteotoxic proteins in mammalian cells XREF_BIBR, thus further verifying the value of C. elegans as a model organism to evaluate the consequences of UPS modulation."
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"For example, researchers have discovered inhibitors, like b-AP15 to covalent inhibition of both USP14 and UCHL5 to induce the cathepsin-dependent apoptosis by inhibiting the UPS system [131]."
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"Together, these results show that, similar to the IIS-regulated UBH-4 in C. elegans ( Figure 7 D), a decreased level of UCHL5 increases UPS activity and enhances degradation of aggregation prone prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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