IndraLab

Statements

USP19 inhibits Mice. 5 / 5
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"Gene knockout studies demonstrate that USP19 negatively regulates TLR3/4-mediated innate immune and inflammatory responses in cells and mice."
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"These data suggest that USP19 attenuates TLR3/4-mediated inflammatory responses in mice."
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"To our surprise, the results indicated that USP19 knockout dramatically prolonged the survival of both cohorts of mice ( Figure 3 A ) and significantly reduced AOM/DSS-induced colon tumor number, volu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Notably, USP19 overexpression reduces ferroptosis and IRI in a SLC7A11-dependent manner in mice."
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"Taken together with the pathological findings described above, the loss of USP19 leads to a favorable brain phenotype in PFF-injected mice, but no apparent beneficial effect on overall survival."
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