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USP2 increases the amount of IRS1. 3 / 3
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"In contrast, Usp2 overexpression induced the expression of PPAR-γ, GLUT4, and IRS1, and reduced the expression of atrogenes under DEX stimulation (Supplementary Fig. 4B)."

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"Knockdown of PPAR-γ reduced and Usp2 overexpression increased the levels of PPAR-γ, IRS1, and GLUT4 in C2C12 cells (Fig. 6A)."

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"Usp2 knockdown reduced the expression of PPAR-γ, GLUT4, and IRS1, and increased atrogene expression under DEX stimulation (Supplementary Fig. 4A)."