IndraLab

Statements

USP1 inhibits cell death. 6 / 6
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"More recently developed compounds SJB2-043 and SJB3-019A inhibited the salvaging of ID1, ID2, ID3, FANC1 and FANCD2 proteins by Usp1 from proteosomal degradation and as a result caused an increase in cell death and sensitisation to DNA damaging agents [XREF_BIBR]."
25962961
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"USP1 knockdown or inhibition arrests EWS cell growth and induces cell death by apoptosis."
37478161
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"Here, we demonstrate that targeting USP1 with a small molecule, can promote ID1 degradation and cell death in multiple leukemic cell lines."
24130053
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"To explore the mechanism of RL-4RH cell death induced by inhibition of USP1, we evaluated the protein levels of p62 and LC3, the autophagy markers."
36352191
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"The two cell lines that did not respond to the CDDP ± pimozide treatment (“nonresponder”) were also insensitive to USP1 silencing–induced cell death after platinum."
31086816
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"These data indicate that loss of USP1 confers apoptosis resistance to β-cells against stress-induced cell death."
30227958