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Ketone body inhibits NLRP3. 19 / 19
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"The Ketone Body beta-Hydroxybutyrate Inhibits NLRP3 Inflammasome-Mediated Inflammation."
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"We also highlight NLRP3 inflammasome inhibition by several ketone body therapies as a promising new treatment strategy for AD."
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"We will also discuss ketone body metabolism by microglia and ketone body inactivation of the NLRP3 inflammasome to attenuate AD pathology."
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"One mechanism for its anti-inflammatory effects is via production of beta-hydroxybutyrate (BHB), a ketone body that blocks the NLRP3 inflammasome and reduces proinflammatory cytokine production (notably, IL-1β) by human monocytes."
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"The ketone body beta-hydroxybutyrate (betaHB) suppresses the NLRP3 inflammasome and alters intracellular signalling pathways in vitro and in animal models; however, this effect has not yet been shown in vivo in humans."
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"For instance, the ketone body β-hydroxybutyrate (BHB), which is generated from fatty acids during starvations, seems to inhibit NLRP3 by a mechanism that requires further clarification but may involve[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"the ketone body BHB) inhibit NLRP3 activation."
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"Others have shown that the ketone body, β-hydroxybutyrate, can prevent both priming and activation of the NLRP3 inflammasome ."
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"In the ketogenesis pathway, HMGCS2 catalyzes the production of β-hydroxybutyrate, a ketone body known to inhibit the NLRP3 inflammasome."
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"In another study in human monocytes, the ketone body β-hydroxybutyrate suppressed NLRP3 activation through inhibition of the K + efflux and ASC oligomerization, which lead to a reduction in IL-1β and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The ketone body β-hydroxybutyrate (BHB)167 inhibits NLRP3 inflammasome-mediated inflammation by preventing K+ efflux."
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"Moreover, the most abundant ketone body, beta-hydroxybutyrate, inhibits the NLRP3 inflammasome in myeloid cells, a key potentiator of age-related inflammation."
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"In a recent study, the ketone body – β-hydroxybutyrate (BHB) was found to suppress NLRP3 activation caused by urate crystals, lipotoxic fatty acids, and ATP."
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"Improvements in lifespan and healthspan by KD fits well with our recent findings that the ketone body BHB inhibits the NLRP3 inflammasome in macrophages and neutrophils , which we have previously linked to age-related inflammation and disease ."
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"β-hydroxybutyrate, a ketone body serving as an alternative source of ATP during an energy deficit, has been shown to abrogate the activating effects of ATP, monosodium urate and ceramide on NLRP3 inflammasome, through diminishing K+ efflux and ASC oligomerization [151]."
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"Mechanistically, the ketone body β-hydroxybutyrate (BHB) deactivated the activation of NLRP3 inflammasome triggered by CoCrMo alloy particles."
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"NLRP3 activation further appears to be inhibited by the activity of the ketone body βHB produced by the KD, suggesting that the modulation of neuroinflammation contributes to KD efficacy (Youm et al., 2015)."
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"One of these ketone bodies , beta-hydroxybutyrate ( BHB ) , inhibits NLRP3 activation induced by a wide variety of stimuli75 ."
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"Ketone bodies inhibit NLRP3 , which may have clinical implications as mice under ketogenic diet show inhibition of aging-induced exacerbation of COVID-19 infection ( 46 ) ."
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