IndraLab

Statements

Ketone body inhibits NLRP3. 10 / 10
| 2 8
reach
"Others have shown that the ketone body, β-hydroxybutyrate, can prevent both priming and activation of the NLRP3 inflammasome ."
30367086
reach
"The ketone body beta-hydroxybutyrate ( β HB) suppresses the NLRP3 inflammasome and alters intracellular signalling pathways in vitro and in animal models; however, this effect has not yet been shown in vivo in humans."
35433045
reach
"β-hydroxybutyrate, a ketone body serving as an alternative source of ATP during an energy deficit, has been shown to abrogate the activating effects of ATP, monosodium urate and ceramide on NLRP3 inflammasome, through diminishing K+ efflux and ASC oligomerization [151]."
32545355
reach
"Mechanistically, the ketone body β-hydroxybutyrate (BHB) deactivated the activation of NLRP3 inflammasome triggered by CoCrMo alloy particles."
35264201
eidos
"One of these ketone bodies , beta-hydroxybutyrate ( BHB ) , inhibits NLRP3 activation induced by a wide variety of stimuli75 ."
31036962
eidos
"Ketone bodies inhibit NLRP3 , which may have clinical implications as mice under ketogenic diet show inhibition of aging-induced exacerbation of COVID-19 infection ( 46 ) ."
34810268
reach
"Improvements in lifespan and healthspan by KD fits well with our recent findings that the ketone body BHB inhibits the NLRP3 inflammasome in macrophages and neutrophils , which we have previously linked to age-related inflammation and disease ."
32694683
reach
"The ketone body β-hydroxybutyrate (BHB)167 inhibits NLRP3 inflammasome-mediated inflammation by preventing K+ efflux."
32550001
reach
"In a recent study, the ketone body – β-hydroxybutyrate (BHB) was found to suppress NLRP3 activation caused by urate crystals, lipotoxic fatty acids, and ATP."
30356809
reach
"Moreover, the most abundant ketone body, β-hydroxybutyrate (BHB), inhibits the NLRP3 inflammasome in myeloid cells, a key potentiator of age-related inflammation."
36775129