IndraLab

Statements

Phosphatase activates KCNK18. 6 / 6
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"The calcium/calmodulin dependent protein phosphatase calcineurin activates TRESK 5-15-fold in Xenopus oocytes XREF_BIBR."
22145024
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"The two-pore domain K (+) channel, TRESK (TWIK related spinal cord K (+) channel, KCNK18) is directly regulated by the calcium/calmodulin dependent phosphatase calcineurin and 14-3-3 adaptor proteins."
20215114
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"The two-pore domain K (+) channel, TRESK (TWIK related spinal cord K (+) channel) is reversibly activated by the calcium/calmodulin dependent protein phosphatase, calcineurin."
18397886
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"The two-pore domain K (+) channel, TRESK (TWIK related spinal cord K (+) channel) is activated in response to the calcium signal by the calcium/calmodulin dependent protein phosphatase, calcineurin."
16569637
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"Cyclosporin A and FK506, specific inhibitors of the calcium/calmodulin dependent protein phosphatase (calcineurin), completely eliminated TRESK activation."
14981085
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"Remarkably, TRESK activation is mediated by the calcium/calmodulin dependent serine/threonine phosphatase, calcineurin and inhibited by calcineurin inhibitors, such as cyclosporine A and FK506 [11]."
23541583