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"Thus, Cavalli-2 should be a useful probe of the spatial configuration of drug binding groups, especially the aromatic side chains of Tyr 652 and Phe 656; substantial interactions with multiple (at least two) Phe 656 side chains seem to be required to understand the large attenuations of block seen with several high-affinity blockers, including flecainide, Cavalli-2 (this study), E-4031, and cisapride in hERG F656A overexpressing mammalian cells and MK-499, cisapride, chloroquine, and clofilium in hERG F656A overexpressing oocytes."