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OTUB2 activates DNA-templated transcription. 2 / 2
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"Third, although we found that OTUB2 promotes the transcription of key glycolytic enzymes, including GLUT1, HK2, and PKM2, we cannot exclude the possibility that OTUB2 may regulate other glycolytic enzymes in addition to PFKFB3 to affect VC development."
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"We examined the expression of Hippo target genes following OTUB2 overexpression or depletion and found that OTUB2 depletion inhibited the transcription of Hippo target genes, including CTGF, AREG, and ANKRD1 in VSMCs, whereas the opposite results were observed in the overexpression group (Figure 3I-J)."
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