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BRCC3 binds SMAD3. 2 / 2

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"Once bound to BRCC36, Smad3 is prevented from entering the nucleus from the cytoplasm and thus, negatively regulating the TGF-β pathway in pulmonary artery smooth muscle cells [ 13 ]."

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"Some researchers have found that BRCC36 can bind to Smad3, the main effector protein of the TGF-β pathway."

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BRCC3 binds SMAD3. 2 / 2

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