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UCHL1 inhibits hydrolase. 6 / 6
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"We found that the experimental data did not agree with the model predictions if the only effect of UCH-L1 was reduced hydrolase activity."
20949132
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"Finally, we found that UCH-L1 modification by HNE decreases its hydrolase activity.The I93M UCH-L1 mutant exhibits reduced hydrolase activity (~ 55% of wild-type), and this mutant displays 80% penetra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12705903
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"Ile93Met mutation in human UCH-L1 gene that decreased hydrolase activity has been linked to a rare, autosomal dominant form of familial PD in German (Leroy et al., 1998)."
16626667
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"Cells were treated with LDN, which acts as a site directed inhibitor of UCH-L1 inhibiting the hydrolase activity."
25999815
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"Monoubiquitination of UCH-L1 was also reported to restrict its hydrolase activity XREF_BIBR, but its effect on the solubility of UCH-L1 has not been studied."
24959670
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"In our previous report, 15dPGJ2 modification of UCH-L1 abolished the protein 's hydrolase activity."
26539913