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UCHL1 inhibits hydrolase. 11 / 11
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"In our previous report, 15dPGJ2 modification of UCH-L1 abolished the protein 's hydrolase activity."
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"Oxidation of Uch-L1, which is seen in PD brains, has been shown to cause the reduction of its hydrolase activity ( Nishikawa et al., 2003; Choi et al., 2004 )."
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"Here, we have demonstrated that UCH-L1 is a natural substrate for the serine protease HtrA2 in the apoptotic pathway and that HtrA2-mediated cleavage of UCH-L1 impaired its hydrolase activity."
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"Cells were treated with LDN, which acts as a site directed inhibitor of UCH-L1 inhibiting the hydrolase activity."
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"Ile93Met mutation in human UCH-L1 gene that decreased hydrolase activity has been linked to a rare, autosomal dominant form of familial PD in German (Leroy et al., 1998)."
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"In vitro, oxidation of recombinant UCHL1 treated with 4-hydroxynonenal, a candidate endogenous mediator of oxidative stress-induced neuronal cell death, caused a loss of its hydrolase activity [126]."
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"Finally, we found that UCH-L1 modification by HNE decreases its hydrolase activity.The I93M UCH-L1 mutant exhibits reduced hydrolase activity (~ 55% of wild-type), and this mutant displays 80% penetra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Monoubiquitination of UCH-L1 was also reported to restrict its hydrolase activity XREF_BIBR, but its effect on the solubility of UCH-L1 has not been studied."
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"The I93M mutation in UCH-L1 reduces its hydrolase activity by about 50%, which has been suggested as a cause for the pathogenesis of PD ( Nishikawa et al., 2003 )."
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"We found that the experimental data did not agree with the model predictions if the only effect of UCH-L1 was reduced hydrolase activity."
20949132
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"Nitrosylation (e.g., via MPTP or rotenone exposure), altered solubility (e.g., MPP + , rotenone, paraquat, 6-OHDA, or iron treatment) or covalent modification of Parkin (DA) diminishes its ubiquitin l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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