IndraLab

Statements

MiR-3940-5p inhibits USP28. 6 / 6
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"MiR-3940-5p suppresses the proliferation of non-small cell lung cancer cells by targeting cyclin D1 and ubiquitin specific peptidase-28 (Ren et al., 2017)."
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"These results confirmed our speculation that miR-3940-5p inhibits NSCLC cell proliferation and promotes apoptosis by targeting CCND1 and USP28."
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"In line with binding data, the results show that miR-3940-5p markedly suppresses the luciferase activity of the WT CCND1 or USP28 3 ' UTR without effect on the MUT 3 ' UTR, which indicates that CCND1 and USP28 are direct targets of miR-3940-5p (XREF_FIG, C and D)."
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"Furthermore, animal study also confirmed that overexpression of miR-3940-5p suppresses the growth of NSCLC tumors and negatively regulates CCND1 and USP28 in vivo."
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"As illustrated in XREF_FIG, A-D, compared with control cells, CCND1 and USP28 are downregulated at both mRNA and protein levels by ectopic expression of miR-3940-5p; however, pcDNA-CCND1 and pcDNA-USP28 robustly overturn this decreased expression of CCND1 and USP28 induced by miR-3940-5p."
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"Results show that CCND1 and USP28 protein expression levels are decreased compared with the control group (XREF_FIG C), suggesting that miR-3940-5p negatively regulates CCND1 and USP28 in vivo."
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