IndraLab

Statements

PCSK7 activates KCNK2. 5 / 5
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"As expected xref we observed activation of TREK1 by LPC or convex membrane curvature induced by negative pressure applied to cell-attached patches; however, although expression of TRPC5 conferred greater current in response to negative pressure, the current lacked the hallmark I – V of TRPC5 xref ."
19324410
reach
"Consistent with this perspective, the LPC activated TREK1 channel is activated by general anaesthetics XREF_BIBR."
19324410
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"Polyunsaturated fatty acids (PUFAs) such as Arachidonic acid (AA), alpha-linolenic acid (ALA), docosahexaenoic acid (DHA) or lysophospholipids (LP) such as lysophosphatidylcholine (LPC) also activate TREK-1 channels and are neuroprotective against both ischemia and seizures induced by kainate injections [22], [29]."
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"As expected XREF_BIBR we observed activation of TREK1 by LPC or convex membrane curvature induced by negative pressure applied to cell attached patches; however, although expression of TRPC5 conferred greater current in response to negative pressure, the current lacked the hallmark I-V of TRPC5 XREF_BIBR."
19324410
sparser
"Additional TREK-1 activation in neurons by LIN or LPC would provide further protection [ xref ]."
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