IndraLab

Statements

BAP1 inhibits transcription, DNA-templated. 4 / 4
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"In general, various molecules regulate SLC7A11, such as tumor suppressor P53, tumor suppressor BRCA1-associated protein 1 (BAP1), activating transcription factor 3/4 (ATF3/ATF4), beclin 1 (BECN1), and nuclear factor erythroid 2-related factor 2 (NRF2) (Figure 3)."
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"Moreover , ZEB1 promoted down-regulation of crucial genes involved in melanocyte differentiation , including BAP1 , melanocyte inducing transcription factor ( MITF9 ) , tyrosinase ( TYR ) , and tyrosinase-related protein 1 ( TYRP ) ."
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"Similarly , BAP1 , an epigenetic regulator and tumor suppressor mutated in various types of cancer , can downregulate the transcription of SLC7A11 and thus potentiate ferroptosis ( Zhang et al ., 2018 ) ."
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"Under glucose starvation , BAP1 can directly bind to the promoter of ATF3 and CHOP , inhibit its transcription , and thus inhibit the UPR and cell death induced by the ER stress ( Figure 2p ) ."
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