IndraLab

Statements

Phosphatidyl-L-serine inhibits NLRP3. 5 / 5
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"Furthermore, PS inhibited the NLRP3 inflammasome 1h after LPS and ATP treatment by suppressing the NF-kappaB pathway, which downregulated Ca 2+ accumulation and mtROS production."
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"These data showed that PS negatively regulated activation of the NLRP3 inflammasome in a time-different manner by inhibiting the NF-kappaB signaling pathway in the early stage and the ER stress response in the late stage."
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"This study is aimed at investigating whether PS downregulate NLRP3 mediated inflammasome by inhibiting nuclear factor-kappaB (NF-kappaB) and endoplasmic reticulum (ER) stress."
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"We demonstrated that PS inhibited NLRP3 inflammasome related cell death in BV2 microglia cells by downregulating Ca 2+ accumulation and mtROS generation."
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"XREF_BIBR XREF_BIBR XREF_BIBR In accordance with these studies, we could confirm that PS expressing ectosomes suppress LPS priming of the NLRP3 inflammasome in vitro."
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