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"Subsequently, the RT-qPCR results demonstrated that miR-454 and USP47 expression levels were significantly decreased in 5-8F/DDP and SUNE-1 and DDP cells following transfection with miR-454 inhibitor or shUSP47 compared with the NC inhibitor and shNC groups, respectively, which suggested that miR-454 inhibitor and shUSP47 downregulated miR-454 and USP47 expression levels in DDP resistant NPC cells, respectively (XREF_FIG)."