IndraLab

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CACNA1A inhibits inflammatory response. 5 / 5
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"To check whether MHP1 could inhibit inflammation and microglia activation, we examined the number of F4/80 positive cells in the ischemic region and the expression of IL-6 and MCP-1 mRNA at 48 hours after the treatment."
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"Collectively, these results indicate that MHP could attenuate inflammation in liver tissue through regulating the secretion of adipokines.4 DISCUSSION."
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"Importantly, MHP1 also inhibited TLR2, 7, 8-induced inflammations , which are other important signals for DAMP in post-ischemic inflammation ."
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"What's more, the TNF-α, IL-6 levels in serum and mRNA expressions (TNF-α, IL-6) in liver tissue were significantly decreased ( Fig. 4 G) (P < 0.05), which demonstrated the Bi-HA/FK866 could induce NF-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To solve the problem, we previously developed a novel partial peptide of RANKL, microglial healing peptide 1 (MHP1), which could reduce ischemic injury by inhibiting Toll-like receptor (TLR) induced inflammation."
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