IndraLab

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USP15 increases the amount of MMP9. 3 / 3
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"Consistently, USP15 shRNA impaired the protein levels of MMP9, N-cadherin, and Vimentin, but recovered E-cadherin expression in GINS1-overexpressing A172 cells, while the USP15 plasmid restored the protein levels of MMP9, N-cadherin, and Vimentin, but attenuated E-cadherin expression in GINS1-silenced U251 cells (Figure 6Q)."
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"USP15 knockdown significantly reduced the proliferation and invasion of NSCLC cells by downregulating the expression of MMP3 and MMP9."
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"Western blotting results showed that the knockdown of USP15 significantly decreased the expression of MMP3 and MMP9 in NSCLC cells compared to negative control ( Fig. 4 A and 4 B)."
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