IndraLab

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COPS6 leads to the ubiquitination of SPOP. 2 / 2
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"Under physiological condition, Csn6 liver cancer tissue demonstrated higher SPOP expression, less expression of MDM2, HMGCS1 and survivin (YAP1 target gene) when compared with Csn6 liver cancer tissue (Figure 6J,K), suggesting that CSN6‐MDM2 axis‐mediated SPOP ubiquitination and consequential HMGCS1 stabilization can be recapitulated in Csn6 mouse liver cancer.2.7 Targeting CSN6-HMGCS1 Axis to Suppress Tumor Growth in NAFLD Related HCC."
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"Thus, CSN6 antagonizes SPOP‐mediated HMGCS1 polyubiquitination.2.6 CSN6-MDM2 Axis-Mediated SPOP Ubiquitination."
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