IndraLab

Statements

BRAP ubiquitinates USP15. 5 / 5
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sparser
"USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15."
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signor
"Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15."
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sparser
"In turn, BRAP can ubiquitylate USP15, which is opposed by its intrinsic catalytic activity."
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sparser
"We have been able to show that USP4 and USP15 can oppose this BRAP ubiquitylation and that BRAP can promote ubiquitylation of catalytically inactive USP15."
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ubibrowser
"UbiNet 2.0"
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