IndraLab

Statements

FCGR1A activates IGF1R. 3 / 3
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"Importantly, the finding of an induction by GD-IgG on hyaluronan production in the face of no response to TSH suggests the potential for GD-IgG activating IGF-1R. In aggregate, the reports of van Zeijl et al ( xref ) may share important similarities with that of Smith and Hoa ( xref )."
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"The TSHR and IGF-IR receptor complexes can be activated by pathogenic IgGs and IGF-I. This activation leads to the production of inflammatory molecules and glycosaminoglycans, which contain hyaluronic acid [ xref ]."
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"Many years later, Pritichard et al. reported that IGF-I and GD-IgG could bind and activate IGF-IR ( xref )."
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