IndraLab

Statements

USP9X activates SMURF1. 2 / 3
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"USP9X can also modulate ubiquitin ligase SMURF1, a negative regulator of TGFbeta and BMP signaling that controls tumor cell migration and invasion by targeting Rho family proteins [XREF_BIBR]-[XREF_BIBR]."
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"In these cells , Ubiquitin Specific Peptidase 9 X-Linked ( USP9X ) stabilizes endogenous SMURF1 , and depletion of USP9X leads to down-regulation of SMURF1 and significantly impaired cellular migration ( Figure 7 ) ( 115 ) ."
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