IndraLab

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OTUB1 decreases the amount of DA2. 2 / 2
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"These data suggest that OTU1 negatively regulates expression of DA1 and DA2 and that its loss of function results in transcriptional activation of these target genes.DA1, a ubiquitin-binding protein, and DA2, a RING-type E3 ubiquitin ligase, are known to interact with each other and negatively regulate the seed and organ size in Arabidopsis (Du et al., 2014, Li and Li, 2014, Li and Li, 2016, Xia et al., 2013)."
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"Consistent with the effect of the OTU1 loss-of-function mutations on the DA1 and DA2 transcription (see Figure 6), their effect on DA2 monoubiquitylation was more pronounced than that on DA1 monoubiquitylation."
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